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Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRP
Author(s) -
Hatton Deborah D.,
Sideris John,
Skinner Martie,
Mankowski Jean,
Bailey Donald B.,
Roberts Jane,
Mirrett Penny
Publication year - 2006
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31286
Subject(s) - fragile x syndrome , autism , childhood autism rating scale , psychology , rating scale , fragile x , clinical psychology , fmr1 , developmental psychology , autism spectrum disorder , medicine , audiology , psychiatry , biochemistry , chemistry , gene
Abstract We examined autistic behavior in a cross‐sectional sample of 179 children with fragile X syndrome (FXS) and a longitudinal subset of 116 children using the Childhood Autism Rating Scale (CARS) to (a) determine a prevalence of autistic behavior in FXS, (b) examine the stability of autistic ratings over time, and (c) assess the association between the fragile X mental retardation protein (FMRP) and autistic behavior. Approximately 21% of the sample of 129 children (25.9% of boys) scored at or above the cutoff for autism. CARS scores increased slowly, yet significantly, over time, and low levels of FMRP were associated with higher mean levels of autistic behavior as measured by the CARS. © 2006 Wiley‐Liss, Inc.