Premium
Overgrowth with severe developmental delay following IVF/ICSI: A newly recognized syndrome?
Author(s) -
Shah Prakesh S.,
Weksberg Rosanna,
Chitayat David
Publication year - 2006
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31274
Subject(s) - intracytoplasmic sperm injection , in vitro fertilisation , medicine , global developmental delay , pathogenesis , genomic imprinting , pregnancy , pediatrics , biology , genetics , phenotype , gene expression , gene , dna methylation
Abstract We report on a child with postnatal overgrowth, noted from 3 months of age, associated with severe developmental delay and refractory seizures. The patient was conceived using in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). The patient's features do not resemble any reported overgrowth syndromes reported so far. We propose that this is a previously unrecognized disorder. The potential role of ICSI/IVF in the pathogenesis of this condition is unknown. No imprinting defect at chromosome 11p15 was identified. © 2006 Wiley‐Liss, Inc.