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Diagnosis and management of heterokaryotypic monochorionic twins
Author(s) -
Lewi Liesbeth,
Blickstein Isaac,
Van Schoubroeck Dominique,
Gloning KarlPhilipp,
Casteels Martine,
Brandenburg Helen,
Fryns JeanPierre,
Deprest Jan
Publication year - 2006
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.31052
Subject(s) - amniocentesis , obstetrics , medicine , monochorionic twins , aneuploidy , prenatal diagnosis , chorionic villus sampling , gynecology , pregnancy , gestational age , fetus , chromosome , biology , genetics , gene
The diagnosis, management, and outcome of six consecutive heterokaryotypic monochorionic twins were evaluated. All suspected cases, based on discordant ultrasound findings, underwent amniocentesis of both sacs. Two cases also had chorionic villous sampling (CVS). Dual amniocentesis was superior to CVS in diagnosing heterokaryotypic monochorionic twins. In four cases, the X‐chromosome was involved and autosomal aneuploidy was noted in the others. In five cases, the anomalous twin was selectively reduced by cord coagulation. All pregnancies ended with a phenotypically normal liveborn and all children are developing normally at 1–7 years of age. © 2006 Wiley‐Liss, Inc.