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Growth hormone benefits children with 18q deletions
Author(s) -
Cody Jannine D.,
SemrudClikeman Margaret,
Hardies L. Jean,
Lancaster Jack,
Ghidoni Patricia D.,
Schaub Rebecca L.,
Thompson Nora M.,
Wells Lynda,
Cornell John E.,
Love Tanzy M.,
Fox Peter T.,
Leach Robin J.,
Kaye Celia I.,
Hale Daniel E.
Publication year - 2005
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.30848
Subject(s) - white matter , growth hormone , brain size , growth hormone deficiency , hormone , medicine , chromosome , endocrinology , intelligence quotient , cognition , psychology , biology , audiology , neuroscience , genetics , magnetic resonance imaging , gene , radiology
Most individuals with constitutional deletions of chromosome 18q have developmental delays, dysmyelination of the brain, and growth failure due to growth hormone deficiency. We monitored the effects of growth hormone treatment by evaluating 23 individuals for changes in growth, nonverbal intelligence quotient (nIQ), and quantitative brain MRI changes. Over an average of 37 months, the treated group of 13 children had an average nIQ increase of 17 points, an increase in height standard deviation score of 1.7, and significant change in T1 relaxation times in the caudate and frontal white matter. Cognitive changes of this magnitude are clinically significant and are anticipated to have an effect on the long‐term outcomes for the treated individuals. © 2005 Wiley‐Liss, Inc.