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Familial neurocardiogenic (vasovagal) syncope
Author(s) -
Newton Julia L.,
Kerr Simon,
Pairman Jessie,
McLaren Andrew,
Norton Michael,
Kenny Rose Anne,
Morris Christopher M.
Publication year - 2005
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.30572
Subject(s) - vasovagal syncope , bradycardia , syncope (phonology) , etiology , medicine , cardiology , autonomic function , anesthesia , heart rate , blood pressure , heart rate variability
Vasovagal syncope (VSS) is an exaggerated tendency towards the common faint caused by a sudden and profound hypotension with or without bradycardia. The etiology of VVS is unknown though several lines of evidence indicate central and peripheral abnormalities of sympathetic function. Studies however indicate a strong heritable component to the etiology of VVS in over 20% of cases. Here, we report the findings from a family that shows apparently autosomal dominant VVS in at least three generations. Clinical findings included an absence of any discernible cardiac or autonomic abnormalities and reproducible hypotension on tilt table testing in affected family members. © 2005 Wiley‐Liss, Inc.