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Choanal atresia associated with prenatal methimazole exposure: Three new patients
Author(s) -
Barbero P.,
Ricagni C.,
Mercado G.,
Bronberg R.,
Torrado M.
Publication year - 2004
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20668
Subject(s) - choanal atresia , propylthiouracil , methimazole , in utero , medicine , antithyroid agent , fetus , atresia , pregnancy , graves' disease , pediatrics , biology , thyroid , genetics
We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus. © 2004 Wiley‐Liss, Inc.