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Cutaneous T‐cell lymphoma in a 21‐year‐old male with Wolf–Hirschhorn syndrome
Author(s) -
Batton Beau,
Amanullah Adoor,
Main Charles,
Fivenson David,
Jamil Samir
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20608
Subject(s) - malignancy , lymphoma , chromosome 4 , medicine , chromosome , cutaneous t cell lymphoma , pathology , biology , genetics , mycosis fungoides , gene
We describe a case of cutaneous T‐cell lymphoma occurring in a 21‐year‐old male with Wolf–Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma. © 2003 Wiley‐Liss, Inc.