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Gastrointestinal polyposis syndromes
Author(s) -
Bronner Mary P.
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20476
Subject(s) - medicine , gastrointestinal tract , genetic testing , cancer , genetic predisposition , lynch syndrome , bioinformatics , colorectal cancer , disease , biology , dna mismatch repair
Numerous polyposis syndromes involve the gastrointestinal (GI) tract, including both non-hereditary and hereditary types. Causative genes are now known for the seven major syndromes. Genetic and clinicopathologic features are reviewed here and cancer predisposition is emphasized. Genetic testing is available for the GI polyposis syndromes, and can be accessed through GeneTests-GeneClinics on the Internet at http://www.genetests.org/. The website is available at no cost and is a publicly funded medical genetics resource for health care providers and researchers.