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Autosomal trisomy and maternal use of multivitamin supplements
Author(s) -
Botto Lorenzo D.,
Mulinare Joseph,
Yang Quanhe,
Liu Yecai,
Erickson J. David
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20436
Subject(s) - multivitamin , trisomy , odds ratio , down syndrome , pregnancy , aneuploidy , medicine , confidence interval , obstetrics , population , gynecology , physiology , biology , genetics , chromosome , gene , vitamin , psychiatry , environmental health
Recent reports suggest that women carrying certain polymorphisms of folate genes associated with suboptimal folate status might be at increased risk for having a child with Down syndrome or other autosomal trisomies, and hypothesized that maternal use of multivitamin supplements might reduce such risk. To evaluate this hypothesis, we examined data from a population‐based case‐control study, and contrasted cases of Down syndrome, trisomy 18, and trisomy 13, with unaffected controls. Periconceptional multivitamin use, compared to no such use, was associated with an odds ratio (OR) of 0.9 (95% confidence interval [CI], 0.6–1.3) for having a pregnancy affected by an autosomal trisomy. The OR was 0.8 (95% CI, 0.5–1.3) for Down syndrome and 1.4 (95% CI, 0.5–3.6) for trisomies 13 and 18, with little variation by maternal race or age. Periconceptional multivitamin use was not associated with a major reduction in the risk for common autosomal trisomies. Published 2003 Wiley‐Liss, Inc.