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Congenital deficiency of alpha‐fetoprotein and associated chromosomal abnormality in the placenta
Author(s) -
Sharony Reuven,
Amiel Aliza,
Bouaron Nitsan,
Kidron Debora,
Itzhaky Dganit,
Fejgin Moshe
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20397
Subject(s) - abnormality , placenta , pathological , immunohistochemistry , pathology , alpha fetoprotein , stain , alpha (finance) , biology , medicine , pregnancy , staining , fetus , genetics , construct validity , psychiatry , hepatocellular carcinoma , patient satisfaction , nursing
In this study we describe two patients with congenital absence of alpha‐fetoprotein (AFP). The pathological examination results, including an immunohistochemical stain, which define qualitatively the levels of AFP detected by the biochemical studies and the comparative genomic hybridization (CGH) are enclosed. A description of the suggested functions of AFP and the means of its production are set forth. An explanation is suggested for the lack of symptoms in a newborn with undetectable levels of AFP and the mechanism by which this condition might occur. © 2003 Wiley‐Liss, Inc.