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Association between genetic variation in the Y chromosome and hypertension in myocardial infarction patients
Author(s) -
García Eliecer Coto,
González Pelayo,
Castro Mónica G.,
Alvarez Ruth,
Reguero Julián R.,
Batalla Alberto,
Cortina Arturo,
Alvarez Victoria
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20376
Subject(s) - single nucleotide polymorphism , blood pressure , myocardial infarction , medicine , allele , snp , biology , cardiology , population , genetics , genotype , gene , environmental health
A single nucleotide polymorphism (SNP) in chromosome Y has been associated with blood pressure. In men, the risk of suffering from cardiovascular diseases, including coronary artery disease, could be influenced by one or more loci on chromosome Y. We genotyped 208 men who had suffered an early episode of myocardial infarction (MI) (≤55 years) and 178 healthy control men for two Y‐polymorphisms (a Hind III polymorphism in an alphoid satellite in the centromeric non‐recombining region and the −2627 T/C in the SRY gene). Frequencies were compared through a χ 2 ‐test. Frequencies for the two polymorphisms did not differ between patients and controls. The alphoid‐ Hind III polymorphism was not related to blood pressures in our population ( Hind III+: diastolic, 80 ± 2; systolic, 129 ± 5. Hind III−: diastolic, 80 ± 2; systolic, 128 ± 3). Seventy‐six patients (37%) were hypertensives and had a significantly higher frequency of the Hind III+ allele compared to the normotensive patients (46 and 26%, respectively; P = 0.028). According to our data, the alphoid‐ Hind III polymorphism in chromosome Y was not associated with differences in blood pressure in men from Asturias (Northern Spain). However, the Hind III+ allele increased the risk of suffering an early episode of MI among hypertensives. © 2003 Wiley‐Liss, Inc.