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Expression of class μ glutathione‐S‐transferase in human liver and its association with hepatopathies
Author(s) -
Engracia V.,
Leite M.M.B.S.,
Pagotto R.C.,
Zucoloto S.,
Barbosa C.A.A.,
Mestriner M.A.
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20364
Subject(s) - phenotype , odds ratio , medicine , allele , incidence (geometry) , ethnic group , biology , genetics , gastroenterology , demography , gene , physics , sociology , anthropology , optics
We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub‐sample of 66 alcoholic individuals compared with 399 non‐alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. An excess of null phenotypes (374/611) was observed, and the allelic distribution was: GSTM1*A = 0.168, *B = 0.089, and *0 (null) = 0.743. © 2003 Wiley‐Liss, Inc.