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Human disorganization complex, as a polytopic blastogenesis defect: A new case
Author(s) -
Delgado Luengo Wilmer Noé,
Luisa Hernández Rodríguez María,
Valbuena Pirela Ivonne,
González Ferrer Sandra,
Estrada Corona Pedro,
Chacón Fonseca Inara,
Delgado Luengo Juana,
MoralesMachín Alisandra,
Borjas Fuentes Lisbeth,
Caridad Martínez Basalo María,
Chacín José
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20307
Subject(s) - computer science
We describe a baby girl of 4,000 g and 55 cm with supernumerary, malformed, and partially duplicated lower limbs, malformed and partially duplicated pelvis, spina bifida, coccygeal dermal sinus, ectopic anus located in the right buttock, duplicated internal genitalia, rectovaginal fistula, ileal atresia, Meckel diverticulum, and various renal system anomalies. We think that this phenotype is a new case of disorganization in humans (DsH) and postulate that this condition constitutes a polytopic defect of the blastogenesis. In this case, the presence of a malformation pattern involving structures in different parts of the body and organs derived from all of the germ layers, suggests that the pathogenetic event most probably occurred during blastogenesis affecting various progenitors fields. © 2003 Wiley‐Liss, Inc.