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A genome‐wide scan for loci predisposing to non‐syndromic cleft lip with or without cleft palate in two large Syrian families
Author(s) -
Wyszynski Diego F.,
AlbachaHejazi Hasan,
Aldirani Mohammed,
Hammod Moustafa,
Shkair Hikmat,
Karam Ahmed,
Alashkar Jehad,
Holmes Taura N.,
Pugh Elizabeth W.,
Doheny Kimberly F.,
McIntosh Iain,
Beaty Terri H.,
BaileyWilson Joan E.
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20283
Subject(s) - locus (genetics) , genetics , genome scan , genetic linkage , candidate gene , biology , genome , etiology , chromosome , gene , medicine , microsatellite , pathology , allele
Abstract Non‐syndromic cleft lip with/without cleft palate (CL/P) is a common, usually non‐fatal birth defect of complex etiology. Several segregation analyses have demonstrated that genetic factors are important in the pathogenesis of CL/P, most likely through the interaction of several genes of modest effects. The aim of this study was to perform a genome‐wide linkage analysis to identify/search for candidate gene loci for CL/P. We conducted a genome‐wide search in two large, relatively isolated Syrian families, each one with a large number of cases with CL/P (18 in family 1 and 4 in family 2). A locus with a multipoint LOD score of 2.80 and a 2‐point non‐parametric MLS LOD of 3.0 was detected on 17p13.1. Other chromosomal regions with multipoint LOD scores ≥ 1.2 ( P ≤ 0.01) included 3p21.2, 4q32.1, and 7q34. These data indicate the possible presence of several susceptibility loci for CL/P and identify a strong candidate locus for this common birth defect on chromosome 17p13. Published 2003 Wiley‐Liss, Inc.