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Lambert–Eaton Myasthenic syndrome in a child with an autoimmune phenotype
Author(s) -
Hoffman William H.,
Helman Sandra W.,
Sekul Elizabeth,
Carroll James E.,
Vega Roger A.
Publication year - 2003
Publication title -
american journal of medical genetics part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.064
H-Index - 112
eISSN - 1552-4833
pISSN - 1552-4825
DOI - 10.1002/ajmg.a.20022
Subject(s) - vitiligo , medicine , autoimmunity , autoantibody , immunology , autoimmune disease , psoriasis , disease , antibody
We report on a child with a family history of autoimmune defects, who presented at the age of 3½ years with alopecia and Graves disease. He subsequently developed vitiligo and psoriasis. At 9½ years, he developed an autoimmune form of Lambert–Eaton Myasthenic syndrome (LEMS) with a significant elevation of glutamic acid decarboxylase (GAD) autoantibodies. Shortly thereafter he developed chronic urticaria. HLA associations were present for Graves disease, vitiligo, psoriasis, and IgA deficiency. There was also evidence of autoimmunity involving the pancreatic islet cells and gastric parietal cells. © 2003 Wiley‐Liss, Inc.