Open AccessHead circumference of children with Down syndrome (0–36 months)
Author(s) -
Palmer Christina G. S.,
Cronk Christine,
Pueschel Siegfried M.,
Wisniewski Krystyna E.,
Laxova Renata,
Crocker Allen C.,
Pauli Richard M.
Publication year - 1992
Publication title -
american journal of medical genetics
Language(s) - English
Resource type - Journals
eISSN - 1096-8628
pISSN - 0148-7299
DOI - 10.1002/ajmg.1320420114
Subject(s) - head circumference , medicine , circumference , down syndrome , pediatrics , longitudinal study , demography , biology , mathematics , pregnancy , birth weight , pathology , genetics , geometry , psychiatry , sociology
This study provides statistically appropriate head circumference reference curves for males and females with Down syndrome (DS) from birth to 36 months of age. A total of 239 males and 182 females from five study populations, yielding a combination of cross‐sectional and longitudinal data, were used for the analysis. The method of least squares was used to test the fit of the growth model y = a + bx + c[log(x + 1)], where x is age in months. These standardized curves should provide information of value in the medical, physical, and developmental management of children with DS.