Premium
Relationship between locations of chromosome breaks induced by vinyl chloride monomer and lymphocytosis
Author(s) -
Fučić Aleksandra,
Hitrec Vlasta,
GarajVrhovac Vera,
Barkovic Danica,
Kubelka Dragan
Publication year - 1995
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700270409
Subject(s) - medicine , lymphocytosis , vinyl chloride , monomer , occupational exposure , immunology , environmental health , organic chemistry , chemistry , copolymer , polymer
The distribution of vinyl chloride monomer (VCM)‐induced chromosome breaks was studied in cultured lymphocytes of subjects occupationally exposed to this gas. In the examined subjects, the mean group value of chromosome aberrations is 6.5% and for sister chromatid exchange (SCE) frequencies, the mean value per cell is 7.9. These values are significantly higher than in the control population. Occupational exposure to VCM caused lymphocytosis together with disturbances of mitogenic activity in lymphocytes stimulated by phytohaemagglutinin. The results of G‐banding showed that sites of chromosome breakpoints caused by VCM can be related to the lymphatic tissue disorders. © 1995 Wiley‐Liss, Inc.