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Occupational exposure to lead, kidney function tests, and blood pressure
Author(s) -
Santos Antonio Cardozo Dos,
Colacciopo Sergio,
Bó Creuza M. R. Dal,
Santos Neife Aparecida Guinaim Dos
Publication year - 1994
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700260506
Subject(s) - medicine , blood pressure , renal function , kidney , urine , urinary system , albumin , toxicity , cardiology , mean arterial pressure , physiology , endocrinology , heart rate
In the present study we examined sensitive biochemical markers of kidney function and damage in 166 workers exposed to lead and in 60 control workers. The objective was to investigate the chronic renal toxicity of lead and its possible correlation with arterial pressure. Diastolic arterial pressure was higher in the exposed group (p < 0.05), but the two groups did not differ in systolic pressure. Median activity of urinary N‐acetyl‐β‐D‐glucosaminidase was higher in the exposed group (p < 0.001), and correlated with blood lead levels (p < 0.001) and duration of exposure (p < 0.001), but not with arterial pressure. The other indicators studied, γ‐glutamyl‐transpeptidase and alanine‐ami‐nopeptidase activity, urine albumin, and total urine protein, were not higher than in the control group and were not correlated with blood lead, duration of exposure, or arterial pressure.