Premium
Microorganism‐induced or enhanced mediator release: A possible mechanism in organic dust related diseases
Author(s) -
Norn Svend
Publication year - 1994
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700250124
Subject(s) - medicine , mediator , mechanism (biology) , microorganism , environmental chemistry , biophysics , environmental health , bacteria , genetics , biology , philosophy , chemistry , epistemology
Bacteria were found to trigger mediator release, including histamine, leukotriene B 4 , and prostaglandin D 2 . Furthermore, histamine release caused by allergens as well as by nonimmunological reactions was enhanced by bacteria, endotoxins, and spores from molds. Mediator release and its enhancement play a crucial role for bronchoconstriction and inflammatory events in the airways. These effects of allergens, microorganisms, and other noxious agents in dusts may, therefore, in concert be responsible for the symptoms in organic dust related diseases. © 1994 Wiley‐Liss, Inc.