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Investigation and evaluation of zinc protoporphyrin as a diagnostic indicator in lead intoxication
Author(s) -
Zhang Jimei
Publication year - 1993
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700240607
Subject(s) - zinc protoporphyrin , medicine , lead poisoning , lead exposure , chelation therapy , lead smelting , environmental health , lead intoxication , toxicology , environmental chemistry , smelting , metallurgy , cats , heme , biochemistry , chemistry , materials science , thalassemia , biology , enzyme , psychiatry
To evaluate the utility of zinc protoporphyrin (ZPP) as an indicator of lead exposure, we examined 128 workers employed at a battery storage plant and two smelters, 343 persons who lived within 200 m of the plants, and 217 controls. Based on Chinese criteria, the “normal” ZPP value among inhabitants of Shaanxi Province was determined to be 85 μg/100 ml. ZPP proved to be a more sensitive and specific indicator of lead exposure, at both high and lower levels, than PbB or PbU. Among 115 patients who underwent chelation therapy for lead poisoning, ZPP also proved to be a valid index of recovery. © 1993 Wiley‐Liss, Inc.