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A case‐control study of cancer of the nose and paranasal sinuses and occupational exposures
Author(s) -
Comba Pietro,
Battista Giuseppe,
Belli Stefano,
De Capua Bruno,
Merler Enzo,
Orsi Daniela,
Rodella Stefania,
Vindigni Carla,
Axelson Olav
Publication year - 1992
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700220406
Subject(s) - medicine , paranasal sinuses , odds ratio , nose , confidence interval , occupational disease , case control study , occupational exposure , cancer , epidemiology , surgery , environmental health
Abstract The association between nasal cancer and various occupations was investigated in a case‐control study in the provinces of Verona and Vicenza (northeastern Italy) and Siena (central Italy). Cases of malignant epithelial neoplasm of the nasal cavities and paranasal sinuses diagnosed in the years 1982–1987 in the hospitals of Verona, Legnago, Bussolengo, Vicenza, and Siena comprised the study. Controls were patients admitted to the same hospitals as the cases, with any diagnosis except chronic rhino‐sinusal disease and nasal bleeding. Age, gender, residency, and date of admission were taken into account by matching. Cases and controls, or their next of kin, were interviewed or required to fill in a mailed questionnaire; the overall response rate was 70%. Altogether, 78 cases and 254 controls provided information on occupational history. Significantly increased risks were associated (in males) with work in the wood industry (odds ratio [O.R.]: 5.8; 90% confidence interval [C.I.]: (2.2–16) and in the leather industry (6.8; 1.9–25). Textile workers, furnacemen, construction workers, and workers with possible exposure to organic dusts showed increased risks even if statistical significance was not reached.