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Pleural malignant mesothelioma in Tuscany, Italy (1970–1988): I. Anatomo‐pathologic aspects
Author(s) -
Dini Sergio,
Santucci Marco,
Biancalani Mauro,
Pingitore Raffaele,
Lopane Paolo,
Tosi Piero,
Megha Tiziana,
Sforza Vincenzo
Publication year - 1992
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700210412
Subject(s) - medicine , mesothelioma , pathology , asbestos , metastatic carcinoma , carcinoma , pleural disease , immunohistochemistry , respiratory disease , lung , materials science , metallurgy
Our investigation did not confirm the general experience that significant numbers of cases initially considered malignant mesothelioma or metastatic carcinoma are actually found to be metastatic carcinoma or malignant mesothelioma, respectively, upon deeper investigation using ancillary techniques (e.g., histochemistry, immunohistochemistry, electron microscopy). Well‐trained pathologists, expert in thoraco‐pulmonary pathology, have a high inter‐ and intra‐rater agreement and significantly better results than standard hospital pathologists in correctly differentiating malignant mesothelioma from metastatic carcinoma. Therefore, epidemiologic investigations which exclude an accurate and rigorous reevaluation of the histologic slides have to be considered unreliable, unless the data come from a specialized medical center experienced in this type of pathology.