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The association between hydrocarbon exposure and anti‐glomerular basement membrane antibody‐mediated disease (Goodpasture's syndrome)
Author(s) -
Bombassei Gregory J.,
Kaplan Andre A.
Publication year - 1992
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700210204
Subject(s) - medicine , goodpasture's syndrome , goodpasture syndrome , basement membrane , antibody , disease , pathology , glomerular basement membrane , glomerulonephritis , immunology , virology , kidney
Despite numerous reports suggesting a relationship between hydrocarbon exposure and Goodpasture's syndrome, the nature of this association is still undefined. The present review was motivated by a patient with Goodpasture's syndrome who wondered if his illness was employment related. The patient had been working in an automobile servicing garage, where he was in frequent contact with a wide array of hydrocarbon solvents. Previous reports linking hydrocarbon exposure to Goodpasture's syndrome and anti‐GBM antibody‐mediated nephritis are analysed. A total of seventeen papers presenting 31 patient with hydrocarbon exposure and anti‐GBM antibody‐mediated disease are reviewed. The results suggest a causal relationship. Specific hydrocarbons implicated as potential toxins are listed, epidemiologic data are reviewed, and the association with cigarette smoking is discussed.