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Chromosomal aberrations, sister chromatid exchanges, and urinary thioethers in nurses handling antineoplastic drugs
Author(s) -
Sarto Franco,
Trevisan Andrea,
Tomanin Rosella,
Canova Arianna,
Fiorentino Mario
Publication year - 1990
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700180607
Subject(s) - medicine , sister chromatids , antineoplastic drugs , urinary system , sister chromatid exchange , occupational exposure , toxicology , physiology , genetics , emergency medicine , pharmacology , chromosome , biology , gene , in vitro
In this study we examined the structural chromosomal aberrations (CA) and sister chromatid exchanges (SCE) of 12 nurses handling moderate quantities of antineoplastic drugs. Urinary thioethers were also measured to assess the potential exposure to alkyl‐ating drugs. Two control groups with similar mean age and smoking habits and working in the same hospital were also studied: 1) control clerks and 2) control nurses. Our study did not show any clear increase of chromosomal damage in exposed nurses as compared to controls. However, CA in control nurses were significantly increased (p = 0.05) with respect to control clerks. The results of baseline urinary excretion of thioethers were statistically higher (p < 0.02) in exposed subjects than in control clerks.