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Effects of organophosphate insecticide residue variability on reentry intervals
Author(s) -
Popendorf William J.
Publication year - 1990
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700180312
Subject(s) - medicine , organophosphate , aché , crew , cohort , cholinesterase , acetylcholinesterase , toxicology , residue (chemistry) , pesticide , biology , ecology , enzyme , biochemistry , aeronautics , engineering
A stochastic simulation program was written to study the importance of residue variability in predicting excessive chronic (seasonal) cholinesterase (AChE) inhibition and acute illness among a cohort of agricultural harvesters grouped into crews exposed to AChE‐inhibiting insecticides. It was concluded that residue variability can substantially affect the cohort's AChE level only for daily mean AChE inhibitions below 4% per day, increasing end‐of‐season mean AChE inhibition but actually decreasing the cohort's end‐of‐season variability. The incidence of acute individual and group (crew) AChE inhibitions in excess of that potentially producing clinical symptoms (assumed herein to be >50% in a day), exhibits a fairly clear boundary as a function of a combination of the residue's mean and deviation. The predicted acute response accurately parallelled reported rates, thus validating the simulation model.