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Case‐control study on occupational exposure to diesel exhaust and lung cancer risk
Author(s) -
Md Paolo Boffetta,,
Harris Randall E.,
Wynder Ernst L.
Publication year - 1990
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700170504
Subject(s) - medicine , lung cancer , odds ratio , confidence interval , confounding , diesel exhaust , case control study , occupational exposure , environmental health , asbestos , cancer , toxicology , diesel fuel , waste management , materials science , engineering , metallurgy , biology
The association between lung cancer and occupations with probable exposure to diesel exhaust (DE) was studied among 2,584 cases and 5,099 hospital controls. The crudeodds ratio (OR) for probable exposure was 1.31 (95% confidence interval [CI] 1.09–1.57), but adjustment for smoking and other confounders reduced the estimate to 0.95 (95% CI = 0.78–1.16). Similar results were observed for truck drivers, the only occupational category large enough for separate analysis. Data on self‐reported exposure for 477 cases and 946 controls revealed a crude OR of 1.45 (95% CI = 0.93–2.27), which was reduced to 1.21 (95% CI = 0.78–2.02) after controlling for smoking and other confounders. The present results and a review of the literature do not definitively support an etiologic association between DE exposure and elevated lung cancer risk.