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Dose‐excretion relationship in tetrachloroethylene‐exposed workers and the effect of tetrachloroethylene co‐exposure on trichloroethylene metabolism
Author(s) -
Seiji Kazunori,
Inoue Osamu,
Jin Chui,
Liu YuTang,
Cai ShiXiong,
Ohashi Mariko,
Watanabe Takao,
Nakatsuka Haruo,
Kawai Toshio,
Ikeda Masayuki
Publication year - 1989
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700160607
Subject(s) - tetrachloroethylene , trichloroethylene , urine , metabolite , urinalysis , medicine , excretion , physiology , occupational exposure , toxicokinetics , toxicology , urinary system , environmental chemistry , toxicity , chemistry , environmental health , biology
Personal monitoring of 8‐hour time‐weighted average intensity of exposure with diffuse samplers and analysis of shift‐end urine for total trichloro‐compounds (TTC) and other metabolites were conducted in two groups of workers in China, one (121 subjects) exposed to tetrachloroethylene (TETRA) alone, and the other (38 subjects) exposed to a mixture of TETRA and trichloroethylene (TRI). Urinalysis was also performed on samples from 103 non‐exposed controls. A linear exposure‐excretion relationship could be observed in both groups of workers. Comparison of these results with those of Japanese TETRA‐workers suggested the presence of ethnic difference in TETRA metabolism. Urinary metabolite levels were markedly lower in the mixed (TETRA + TRI) exposure group as compared to previous findings in a group exposed to TRI alone. The observation indicates that metabolism of TRI is suppressed by the co‐exposure to TETRA in humans.