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Bladder tumors in two young males occupationally exposed to MBOCA
Author(s) -
Ward Elizabeth,
Halperin William,
Thun Michael,
Grossman H. Barton,
Fink Burton,
Koss Leopold,
Osorio Ana Maria,
Schulte Paul
Publication year - 1988
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700140304
Subject(s) - medicine , asymptomatic , carcinogen , incidence (geometry) , physiology , bladder cancer , pathology , bladder neoplasm , gastroenterology , cancer , biology , genetics , physics , optics
MBOCA (4,4′ methylenebis (2‐chloroaniline) is a structural analogue of benzidine and is carcinogenic in mice, rats, and dogs. MBOCA has not yet been demonstrated to be carcinogenic in humans and is not regulated as an occupational carcinogen in the United States. We report two noninvasive papillary tumors of the bladder identified in a screening study of 540 workers exposed to MBOCA during its production at a Michigan chemical plant from 1968 to 1979. Both tumors occurred in men under 30 years old who had never smoked. Although the prevalence of grade 1‐2 tumors among asymptomatic males in this age group is unknown, the incidence of clinically apparent tumors on U.S. males aged 25‐29 is only 1 per 100,000 per year. The detection of the two tumors in young, nonsmoking males is consistent with the hypothesis that MBOCA induces bladder neoplasms in humans.