Premium
In vivo bone lead measurements: A rapid monitoring method for cumulative lead exposure
Author(s) -
Wielopolski U.,
Ellis K. J.,
Vaswani A. N.,
Cohn S. H.,
Greenberg A.,
Puschett J. B.,
Parkinson D. K.,
Fetterolf D. E.,
Landrigan P. J.
Publication year - 1986
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700090304
Subject(s) - lead (geology) , medicine , in vivo , excretion , lead exposure , lead poisoning , zinc protoporphyrin , endocrinology , physiology , biochemistry , chemistry , biology , microbiology and biotechnology , cats , paleontology , psychiatry , heme , enzyme
Lead concentrations (μg/g wet weight) in human bone (tibia) were measured noninvasively in vivo employing an X‐ray fluorescence technique. Forty‐five workers who had been subjected to chronic industrial exposure were found to have a mean bone lead content of 52.9 μg/g wet weight (0 to 198 μg/g). In addition to bone lead content, blood lead, body burden of lead as assessed by urinary lead excretion after EDTA chelation, zinc protoporphyrin, and unstimulated urinary lead excretion were evaluated. The results suggest that the in vivo measurement of tibia lead content may serve as an acceptable indicator of body lead burden and provide a practical technique for lead screening purposes. The correlation coefficient between X‐ray fluorescence findings and lead excretion following Ca‐EDTA administration is 0.69: p < 0.001.