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The role of macrophages and immunocytes in the pathogenesis of pulmonary diseases due to mineral dusts
Author(s) -
Pernis Benvenuto,
Vigliani Enrico C.
Publication year - 1982
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700030203
Subject(s) - pathogenesis , immune system , medicine , stimulation , immunology
Abstract There is considerable evidence of generalized stimulation of the immune system in pulmonry dust diseases. This stimulation involves both the T‐ and the B‐arms of the immune system. A reasonable explanation of this immune stimulation resides in an effect of the mineral dusts on the macrophages. This effect is likely to be mediated by the production of interleukin‐1. Since the same substance also stimulates fibroblasts, a unified view of the pathogenesis of pulmonary dust diseases is now possible.