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Effects of vanadium on immunologic functions
Author(s) -
Sharma R. P.,
Bourcier D. R.,
Brinkerhoff C. R.,
Christensen S. A.
Publication year - 1981
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700020203
Subject(s) - vanadium , pokeweed mitogen , spleen , in vitro , antibody , medicine , lymphocyte , lipopolysaccharide , immunology , endocrinology , toxicity , biochemistry , biology , chemistry , concanavalin a , inorganic chemistry
Exposure of mice to vanadium caused a dose‐related but nonsignificant decrease in the antibody‐forming cells in the spleen of animals challenged with sheep erythrocytes. Delayed hypersensitivity reaction was not affected in similarly sensitized animals. Serum immunoglobulins were also not altered by the vanadium treatment. Splenic lymphocytes obtained at 1, 4, 8, and 13 wk of exposure to 0, 1, 10, and 50 mg of vanadium per liter of drinking water showed an increased DNA synthesis related to vanadium treatment when cultured in the presence of phytohemagglutinin and pokeweed mitogen but not with bacterial lipopolysaccharide. Addition of vanadium to splenic cultures in vitro caused a marked enhancement of lymphocyte transformation at low concentrations, whereas a decreased cellular proliferation was observed at high concentrations of vanadium.