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Arsenic exposure in a copper smelter as related to histological type of lung cancer
Author(s) -
Wicks Merrill J.,
Archer Victor E.,
Auerbach Oscar,
Kuschner Marvin
Publication year - 1981
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.4700020106
Subject(s) - medicine , lung cancer , arsenic , carcinogen , pathology , lung , occupational exposure , adenocarcinoma , cancer , environmental health , metallurgy , biology , materials science , genetics
Tissue samples from lung cancer patients who had worked at a copper smelter and from controls were collected and classified by a panel of pathologists: 38% of the cancers were found to be adenocarcinomas, compared to 12% among the controls, a statistically significant difference (p<0.05). The predominance of adenocarcinomas was associated with arsenic exposure. This finding is not consistent with Kreyberg's hypothesis that small‐cell undifferentiated and epidermoid carcinomas are the only type that increase in response to inhaled carcinogens [1962].