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Blood biomarkers for vibration‐induced white fingers. A case‐comparison study
Author(s) -
Eriksson Kåre,
Burström Lage,
Nilsson Tohr
Publication year - 2020
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.23148
Subject(s) - medicine , calcitonin , von willebrand factor , cardiology , gastroenterology , endocrinology , platelet
Abstract Background Vibration induced white fingers (VWF) is one form of secondary Raynaud's phenomenon (RP). Methods Vibration exposed workers with RP and vibration exposed controls without RP participated. Blood samples were collected before and after cold challenge exposure (COP). The concentration of von Willebrand factor (vonWf), thrombomodulin (TM), serotonin (SER), endothelin‐1 (ET 1 ), calcitonin gene‐related peptide, or thromboxane A 2 was calculated. The diagnostic usefulness of the substances for ruling in the diagnosis of Raynaud's was evaluated. Results The cases showed a significant lower concentration of vonWf before and after COP, a significant increase of ET 1 and a decrease of TM after COP. The diagnostic usefulness of vonWf showed a likelihood of defining a true case by 35%. Conclusions vonWf, TM, SER, or ET 1 are suggested biomarkers for VWF. Diagnostic evaluation of vonWf showed a likelihood of defining a true case by 35% in the diagnosis of RP related to vibration.