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Malignant mesothelioma in Lynch syndrome: A report of two cases and a review of the literature
Author(s) -
Shih Angela R.,
Kradin Richard L.
Publication year - 2019
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22968
Subject(s) - mesothelioma , asbestos , medicine , malignancy , peritoneal mesothelioma , asbestosis , lynch syndrome , cancer , oncology , pathology , lung , dna mismatch repair , colorectal cancer , materials science , metallurgy
Malignant mesothelioma is a rare and aggressive cancer most typically associated with prior asbestos exposure. The nature of the relationship between asbestos exposure and hereditary familial syndromes predisposing to malignancy has not been determined. We report two Lynch syndrome patients with paraoccupational asbestos exposure who developed diffuse malignant mesothelioma of the pleura or peritoneum. Interestingly, one showed a separate focus of pleural well‐differentiated papillary mesothelioma. It is likely that Lynch syndrome patients are at increased risk for the development of mesothelioma in the setting of exposure to asbestos, even at what is generally considered to be low levels. In the presence of a documented history of low‐level asbestos exposure, patients with genetic predisposition disorders (including Lynch syndrome) should be considered to have an independent risk factor modifying the effects of asbestos exposure.