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Dynamic thiol disulphide homeostasis in operating theater personnel exposed to anesthetic gases
Author(s) -
Kozanhan Betul,
Inanlı Ikbal,
Deniz Cigdem Damla,
Iyisoy Mehmet Sinan,
Neselioğlu Salim,
Sahin Osman,
Akin Fatma,
Tutar Mahmut Sami,
Eren Ibrahim,
Erel Ozcan
Publication year - 2017
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22764
Subject(s) - thiol , homeostasis , oxidative stress , medicine , anxiety , confounding , anesthetic , depression (economics) , occupational exposure , physiology , endocrinology , biochemistry , anesthesia , chemistry , psychiatry , environmental health , economics , macroeconomics
Background The purpose of this study was to investigate the association between dynamic thiol/disulphide homeostasis and occupational exposure to volatile anesthetic gases in operating theater personnel. Decreased blood thiol levels and raised blood disulphide levels serve as biomarkers of oxidative stress. Methods We included 65 subjects occupationally exposed and 55 unexposed healthy medical professionals into the study. A novel method enabled separate measurements of components involved in dynamic thiol/disulphide homeostasis (native thiol, disulphide, and total thiol). To control for the potential confounding effect on oxidative stress of psychological symptoms potentially caused by occupational stress, we used scores obtained from four different anxiety and depression inventories. Results Mean ± standard deviation native thiol was found to be 433.35 ± 30.68 in the exposed group, lower than among controls, 446.61 ± 27.8 ( P = 0.02). Disulphide in the exposed group was 15.78 ± 5.12, higher than among controls, 12.14 ± 5.33 ( P < 0.001). After adjusting for anxiety and depression scores, age and gender, native thiol remained lower and disulphide higher in the exposed group ( P = 0.008 and P < 0.001). Conclusion Dynamic thiol/disulphide homeostasis in workers exposed to anesthetic gases was found to be disturbed after adjusting for the possible contribution of anxiety. We infer that this is due to the oxidative effect of exposure to anesthetic gases.