Premium
Evaluation of adverse health risks associated with antineoplastic drug exposure in nurses at two Chinese hospitals: The effects of implementing a pharmacy intravenous admixture service
Author(s) -
Zhang Xiaoxia,
Zheng Qiaowei,
Lv Yun,
An Mengna,
Zhang Yating,
Wei Youxia,
Feng Weiyi
Publication year - 2016
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22553
Subject(s) - medicine , pharmacy , adverse effect , antineoplastic drugs , occupational exposure , occupational medicine , toxicity , drug , emergency medicine , family medicine , pharmacology
Objective To determine the health risks of antineoplastic drugs (ADs) occupational exposure in nurses and to evaluate the effects of implementing a pharmacy intravenous admixture service (PIVAS) in two Chinese hospitals. Methods The laboratory findings were collected from annual staff physical examination data. Reproductive toxicity and clinical manifestations were self‐reported via a questionnaire. Results Hematotoxicity, organ damage, reproductive toxicity, and clinical manifestations associated with AD exposure were markedly higher in oncology nurses than unexposed nurses. Application of PIVAS led to a significant restoration of the blood cell counts and kidney function, and a reduction in adverse reproductive outcomes among oncology nurses. Pronounced symptoms related to AD exposure were alleviated as well. Conclusion Oncology nurses who work with AD's experienced more adverse health outcomes than unexposed nurses. The health risks to AD were significantly alleviated by implementing a pharmacy intravenous admixture service. Am. J. Ind. Med. 59:264–273, 2016. © 2016 Wiley Periodicals, Inc.