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Occupational exposures and chronic kidney disease: Possible associations with endotoxin and ultrafine particles
Author(s) -
Sponholtz Todd R.,
Sandler Dale P.,
Parks Christine G.,
Applebaum Katie M.
Publication year - 2016
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22541
Subject(s) - medicine , kidney disease , odds ratio , environmental health , logistic regression , confidence interval , case control study , risk factor
Background Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case‐control study. Methods Newly diagnosed cases of CKD (n = 547) and controls (n = 508) from North Carolina provided detailed work histories in telephone interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results There was heterogeneity in the association of CKD and agricultural work, with crop production associated with increased risk and work with livestock associated with decreased risk. Work with cutting/cooling/lubricating oils was associated with a reduced risk. CKD risk was increased for working in dusty conditions. Conclusions CKD risk was reduced in subjects with occupational exposures previously reported to involve endotoxin exposure. Further, exposure to dusty conditions was consistently associated with increased risk of glomerulonephritis across industry, suggesting that research on CKD and ultrafine particulates is needed. Am. J. Ind. Med. 59:1–11, 2016. © 2015 Wiley Periodicals, Inc.