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Working environment and myeloproliferative neoplasm: A population–based case‐control study following a cluster investigation
Author(s) -
Heavner Karyn,
GrossDavis Carol Ann,
Frank Arthur L.,
Newschaffer Craig,
Klotz Judith,
Burstyn Igor
Publication year - 2015
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22451
Subject(s) - medicine , odds ratio , environmental health , case control study , logistic regression , occupational exposure , population , occupational medicine , confidence interval , demography , sociology
Background Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN). Methods We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population–based case‐control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job‐exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression. Results No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure. Conclusions These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs. Am. J. Ind. Med. 58:595–604, 2015. © 2015 Wiley Periodicals, Inc.