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Life‐span carcinogenicity studies on Sprague–Dawley rats exposed to γ‐radiation: Design of the project and report on the tumor occurrence after post‐natal radiation exposure (6 weeks of age) delivered in a single acute exposure
Author(s) -
Soffritti Morando,
Tibaldi Eva,
Bua Luciano,
Padovani Michela,
Falcioni Laura,
Lauriola Michelina,
Manservigi Marco,
Manservisi Fabiana,
Belpoggi Fiorella
Publication year - 2015
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22391
Subject(s) - medicine , life span , radiation exposure , carcinogen , occupational exposure , physiology , toxicology , gerontology , environmental health , nuclear medicine , genetics , biology
Background Experimental long‐term carcinogenicity bioassays conducted on rats and mice proved that ionizing radiation can induce a variety of tumor types. However few studies have been conducted on rats. Methods This report deals with the effects of γ‐radiation in groups of 416–1,051 6‐weeks old Sprague–Dawley rats exposed to 0, 0.1, 1, or 3 Gy of γ‐radiation delivered in a single acute exposure. The experiment lasted for the animals' lifespan and all were necropsied and underwent full histopathological evaluation. Results The results confirm the dose‐related carcinogenic effects of γ‐radiation for several organs and tissues. Moreover they indicate that exposure to 0.1 Gy induces a statistically significant increased incidence in Zymbal gland carcinomas and pancreas islet cell carcinomas in females. Conclusions Our data show that exposure to γ‐radiation induces carcinogenic effects at all tested doses. Am. J. Ind. Med. 58:46–60, 2015. © 2014 Wiley Periodicals, Inc.