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Occupational cadmium exposure‐associated oxidative stress and erythrocyte fragility among jewelry workers in India
Author(s) -
Moitra Subhabrata,
Brashier Bill B.,
Sahu Subhashis
Publication year - 2014
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22336
Subject(s) - malondialdehyde , lipid peroxidation , superoxide dismutase , oxidative stress , erythrocyte fragility , catalase , medicine , antioxidant , endocrinology , physiology , immunology , biochemistry , chemistry , hemolysis
Background Cadmium‐induced pulmonary and renal target organ effects are well‐established although its association with oxidative stress and associated hematological effects for human toxicity remain understudied. Methods In a population of cadmium‐exposed male jewelry manufacturing workers (n = 32) and referents without direct exposure (n = 21), all with urinary cadmium quantification, we measured plasma antioxidant enzymes (catalase, superoxide dismutase), lipid peroxidation (malondialdehyde), erythrocyte fragility, and surface irregularity of the erythrocyte membrane. Results Compared to referents, exposed workers manifested significantly lower plasma antioxidant enzymes, and increased malondialdehyde and erythrocyte fragility (for all, P < 0.01). Consistent with the exposure subcategories, activities of superoxide dismutase and catalase were reduced and lipid peroxidation and erythrocyte fragility were enhanced (P < 0.01 for all) in terms of Cd‐effect indicating a strong impact on hematological system and oxidative stress. Conclusion Cd exposure contributes to oxidative stress and related erythrocyte effects thus making the hematological system another end‐organ target for chronic Cd toxicity. Am. J. Ind. Med. 57:1064–1072, 2014. © 2014 Wiley Periodicals, Inc.