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Increased lung cancer risk among bricklayers in an Italian population‐based case–control study
Author(s) -
Consonni Dario,
De Matteis Sara,
Pesatori Angela C.,
Cattaneo Andrea,
Cavallo Domenico M.,
Lubin Jay H.,
Tucker Margaret,
Bertazzi Pier Alberto,
Caporaso Neil E.,
Wacholder Sholom,
Landi Maria Teresa
Publication year - 2012
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.22017
Subject(s) - medicine , lung cancer , odds ratio , attributable risk , confidence interval , case control study , population , etiology , cancer , adenocarcinoma , surgery , environmental health , demography , sociology
Abstract Background Bricklayers may be at increased risk of lung cancer, although a firm association has not been established. We examined this association within the EAGLE (Environment And Genetics in Lung cancer Etiology) study, a population‐based case–control study conducted in Italy between 2002 and 2005. Methods For men in selected occupations in the construction sector we calculated smoking‐adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs). For bricklayers we estimated the population attributable fraction (PAF) and the attributable community risk (ACR). Results We found increased lung cancer risk for bricklayers (OR 1.57, 95% CI 1.12–2.21; 147 cases, 81 controls). The PAF was 3.9% (95% CI 0.7–7.0), corresponding to an ACR of 4.1 cases annually per 100,000 men (95% CI 0.7–7.3) in the whole community. Among bricklayers, there were increased risks for squamous cell (OR 2.03, 95% CI 1.32–3.13, 56 exposed cases) and small cell carcinomas (OR 2.29, 95% CI 1.29–4.07, 21 exposed cases), while no excess (OR 1.06, 95% CI 0.68–1.65, 41 exposed cases) was found for adenocarcinoma. Conclusions Our findings provide additional evidence of increased lung cancer risk in Italian bricklayers. The association is plausible because they are exposed to several carcinogens, notably crystalline silica. Am. J. Ind. Med. 55:423–428, 2012. © 2012 Wiley Periodicals, Inc.