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Distinguishing the common components of oil‐ and water‐based metalworking fluids for assessment of cancer incidence risk in autoworkers
Author(s) -
Friesen Melissa C.,
Costello Sadie,
Thurston Sally W.,
Eisen Ellen A.
Publication year - 2011
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20932
Subject(s) - medicine , cancer , incidence (geometry) , bladder cancer , lung cancer , cohort , carcinogen , biocide , toxicology , environmental health , pathology , mathematics , biochemistry , biology , chemistry , geometry
Abstract Background Metalworking fluids (MWF)—straight, soluble, and synthetic—have overlapping components. We derived constituent‐based metrics of polycyclic aromatic hydrocarbons (PAHs), water‐based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence. Methods An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0–1. Results For most cancer sites, the constituent‐based metrics resulted in stronger exposure‐disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin. Conclusions Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil‐ and water‐based MWF in epidemiologic studies. Am. J. Ind. Med. 54:450–460, 2011. © 2011 Wiley‐Liss, Inc.