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Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
Author(s) -
Struve Melanie F.,
McManus Brian E.,
Wong Brian A.,
Dorman David C.
Publication year - 2007
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20489
Subject(s) - globus pallidus , putamen , homovanillic acid , basal ganglia , caudate nucleus , medicine , endocrinology , dopamine , neurotransmitter , norepinephrine , serotonin , central nervous system , receptor
Background Manganese neurotoxicity in humans is recognized as a form of parkinsonism with lesions occurring predominantly within the globus pallidus, subthalamic nucleus, putamen, and caudate nucleus. Methods This study evaluated dopamine, 3,4‐dihydroxyphenylacetic acid, homovanillic acid, serotonin, norepinephrine, 5‐hydroxyindoleacetic acid, γ‐aminobutyric acid (GABA), and glutamate concentrations in the globus pallidus, caudate, and putamen of male rhesus monkeys exposed subchronically to either air or manganese sulfate (MnSO 4 ) at 0.06, 0.3, or 1.5 mg Mn/m 3 . Results An approximate 1.5–6‐fold increase (vs. air‐exposed controls) in mean brain manganese concentration was observed following subchronic MnSO 4 exposure. A marginally significant ( P < 0.1) decrease in pallidal GABA and 5‐hydroxyindoleacetic acid concentration and caudate norepinephrine concentration occurred in monkeys exposed to MnSO 4 at 1.5 mg Mn/m 3 . Conclusions Despite the presence of increased tissue manganese concentrations, high‐dose exposure to MnSO 4 was associated with relatively few changes in basal ganglial neurotransmitter concentrations. Am. J. Ind. Med. 50:772–778, 2007. © 2007 Wiley‐Liss, Inc.