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Risks of biliary tract cancer and occupational exposures among Shanghai women textile workers: A case‐cohort study
Author(s) -
Chang ChinKuo,
Astrakianakis George,
Thomas David B.,
Seixas Noah S.,
Camp Janice E.,
Ray Roberta M.,
Li Gao Dao,
Wernli Karen J.,
Li Wenjin,
Fitzgibbons E. Dawn,
Vaughan Thomas L.,
Checkoway Harvey
Publication year - 2006
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20345
Subject(s) - medicine , biliary tract cancer , cohort , hazard ratio , cohort study , environmental health , proportional hazards model , job exposure matrix , population , cancer , demography , confidence interval , gemcitabine , sociology
Background Biliary tract cancer (BTC) is a relatively rare malignancy worldwide. Little is known about potential etiologic contributions of occupational exposures. Methods The associations between occupational exposures to textile dusts and chemicals and BTC are investigated in a cohort of 267,400 women textile workers in Shanghai, China. A nested case‐cohort analysis of 162 BTC cases diagnosed during 1989–1998 was conducted with a reference subcohort of 3,188 workers. Exposures to workplace dusts and chemicals were reconstructed by linking complete work history data with a job‐exposure matrix (JEM). Hazard ratios (HR) and dose‐response trends were estimated by Cox proportional hazards modeling modified for case‐cohort design. Results An elevated risk of ≥1‐year employment in maintenance jobs (HR 2.92, 95% CI: 1.48, 5.73) with a significant trend by duration is observed. Excess risk was also found for ≥20 years exposure to metals (HR 2.50, 95% CI: 1.09, 5.72). Conclusions Long‐term exposure to maintenance work and metals in the textile industry may have increased BTC risk in this population. Am. J. Ind. Med. 49:690–698, 2006. © 2006 Wiley‐Liss, Inc.