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Respiratory response to endotoxin and dust predicts evidence of inflammatory response in volunteers in a swine barn
Author(s) -
Dosman J.A.,
Fukushima Y.,
Senthilselvan A.,
Kirychuk S.P.,
Lawson J.A.,
Pahwa P.,
Cormier Y.,
Hurst T.,
Barber E.M.,
Rhodes C.S.
Publication year - 2006
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20339
Subject(s) - medicine , barn , respiratory system , inflammatory response , immunology , nasal lavage , respiratory disease , pulmonary function testing , physiology , lung , inflammation , allergy , civil engineering , engineering
Background It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV 1 response following swine barn exposure. Methods Naïve males were tested at baseline, low and high endotoxin and dust levels. Subjects were classified as “more responsive” (n = 9) or “less responsive” (n = 11) based on FEV 1 reduction following high endotoxin exposure. Health measures included pulmonary function testing, blood samples and nasal lavage. Environmental samples were collected from the barn. Results White blood cells and blood lymphocytes at low exposure were significantly greater in those who were “more responsive” compared to those who were “less responsive”. There was a significant increase in blood lymphocytes, serum IL6, total nasal lavage cells and nasal IL8 at high exposure among “more responsive” subjects compared to “less responsive” subjects. Conclusions Respiratory response to high‐level endotoxin and dust exposure predicts evidence of inflammatory response throughout a range of endotoxin and dust exposures. Am. J. Ind. Med. 49:761–766, 2006. © 2006 Wiley‐Liss, Inc.