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Symptom onset in the first 2 years of employment at a wood products plant using diisocyanates: Some observations relevant to occupational medical screening
Author(s) -
Wang MeiLin,
Petsonk Edward L.
Publication year - 2004
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20050
Subject(s) - medicine , wheeze , occupational medicine , asthma , phlegm , occupational exposure , occupational asthma , environmental health , pediatrics , pathology , alternative medicine , traditional chinese medicine
Abstract Background Questionnaires are essential tools for medical screening, but their role in monitoring workers at increased risk of occupational asthma (OA) remains indeterminate. Methods Employees who were at a newly established wood products plant without previous exposure to methylene diphenyl diisocyanate (MDI) completed an initial questionnaire and from one to four follow‐up questionnaires during a 2‐year period. Onset of symptoms in 132 workers was assessed by exposure groups and modeled using generalized estimating equations. Results Onset of attacks of dyspnea with wheeze, attacks of dyspnea or cough at rest, and chest tightness were significantly associated with MDI exposure after controlling for age, smoking, and wood dust exposure. Onset of cough on most days was significantly related to smoking and dust. Onset of phlegm production was significantly related to both MDI and dust exposure. Conclusions Onset of certain symptoms is significantly associated with MDI exposure. Early detection of MDI‐associated health effects using a short screening questionnaire appears feasible. Am. J. Ind. Med. 46:226–233, 2004. Published 2004 Wiley‐Liss, Inc.