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Dose‐dependent production of urinary naphthols among workers exposed to jet fuel (JP‐8)
Author(s) -
Serdar Berrin,
Egeghy Peter P.,
Gibson Roger,
Rappaport Stephen M.
Publication year - 2004
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20049
Subject(s) - naphthalene , urinary system , medicine , jet fuel , 1 naphthol , inhalation , toxicology , occupational exposure , irritation , toxicity , physiology , environmental health , immunology , anesthesia , chemistry , biology , organic chemistry
Abstract Background Jet propulsion fuel‐8 (JP‐8) is one of the largest sources of chemical exposures among Air Force personnel. Urinary naphthols have been suggested as useful biomarkers of exposure to JP‐8. Methods Multivariate linear regression models were applied to evaluate the effects of environmental and work‐related factors upon production of urinary naphthols among 323 Air Force personnel. Results Naphthalene exposure, smoking status, and their interaction, plus self‐reported skin irritation explained about two‐thirds of the variation in naphthol levels. The exposure‐smoking interaction was consistent with induction by smoking of one or more steps in the metabolism of naphthalene and naphthalene‐1,2‐oxide (NapO). A supralinear dose‐response relationship was observed between urinary naphthols and naphthalene exposure. Conclusions Urinary naphthols were associated with specific sources of exposure to JP‐8, arising from both inhalation and dermal contact. Smokers and nonsmokers metabolized naphthalene at different rates, consistent with induction of at least two metabolic pathways by smoking. Am. J. Ind. Med. 46:234–244, 2004. © 2004 Wiley‐Liss, Inc.