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Lack of modulating influence of GSTM1 and GSTT1 polymorphisms on urinary biomonitoring markers in coke‐oven workers
Author(s) -
Wu MingTsang,
Pan ChihHong,
Chen ChingYi,
Chen ChiouJong,
Huang LiHung,
Tsai LiYu,
Huang ChiaTsuan,
Ho ChiKung
Publication year - 2004
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.20043
Subject(s) - biomonitoring , coke oven , medicine , occupational exposure , urinary system , environmental health , toxicology , environmental chemistry , coke , waste management , chemistry , engineering , biology
Background Coke‐oven workers (COWs) are occupationally exposed to high concentrations of polycyclic aromatic hydrocarbons (PAHs). Urinary 8‐hydroxy‐2‐deoxyguanosine (8‐OH‐dG) and 1‐hydroxypyrene (1‐OHP) are biological markers of oxidative DNA damage and PAHs metabolism, respectively. In this study, we investigated whether polymorphisms of glutathione S‐transferase ( GSTM1 and GSTT1 ) can modulate the relationship between urinary 8‐OH‐dG and 1‐OHP concentrations among the COWs. Methods This was a cross‐sectional study. Between February and November of 2001, 53 topside‐oven and 130 side‐oven workers with the presence of GSTM1 and GSTT1 genotypes were investigated. Results Urinary 1‐OHP and 8‐OH‐dG concentrations (mean ± SD) in the topside‐oven workers with the presence of GSTM1 were 107.2 ± 107.9 and 15.3 ± 9.7 ng/ml, respectively, which were not significantly different from those in the absence of GSTM1 (84.1 ± 104.5 and 12.8 ± 14.1 ng/ml). The similar insignificant results were also noted in the sideoven workers. For GSTT1 polymorphism, the results remained insignificant. In contrast, individual excretion of urinary 8‐OH‐dG and 1‐OHP concentrations were still highly correlated (Spearman correlation coefficients: r = 0.43, P < 0.0001, n = 183). Conclusions GST may not play a role in the regulation of metabolism of urinary biological markers in COWs. Am. J. Ind. Med. 46:112–119, 2004. © 2004 Wiley‐Liss, Inc.