Premium
The Mechanisms of Action of Reproductive Toxins
Author(s) -
Mattison Donald R.
Publication year - 1983
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.1983.4.1-2.65
Subject(s) - toxicant , reproductive toxicity , medicine , xenobiotic , mechanism of action , hormone , endocrine system , pharmacology , mechanism (biology) , neurohormones , toxicology , toxicity , biology , endocrinology , biochemistry , enzyme , philosophy , epistemology , in vitro
A general discussion of the mechanism of action or reproductive toxins is presented Reproductive toxicants may produce their adverse effects by one of several mechanisms. Some xenobiotics may act directly, either by virtue of chemical reactivity (eg, oocyte destruction by alkylating, agents) or by structural similarity to endogenous molecules (eg, hormone antagonists). Other xenobiolies interrupt reproductive processes indirectly either by metabolic processing to a direct‐acting toxicant (eg, prohormone or metabolic activation to reactive intermediate) or by altering endocrine homeostasis (eg, increased steroid clearance). Selected examples of compounds demonstrating reproductive toxicity by one or more of these mechanisms are tabulated and an extensive bibliography of reproductive toxins is attached.