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Subclinical immunologic and physiologic responses in hexamethylene diisocyanate‐exposed auto body shop workers
Author(s) -
Redlich Carrie A.,
Stowe Meredith H.,
Wisnewski Adam V.,
Eisen Ellen A.,
Karol Meryl H.,
Lemus Ranulfo,
Holm Carole T.,
Chung Joyce S.,
Sparer Judy,
Liu Youcheng,
Woskie Susan R.,
AppiahPippim James,
Gore Rebecca,
Cullen Mark R.
Publication year - 2001
Publication title -
american journal of industrial medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 104
eISSN - 1097-0274
pISSN - 0271-3586
DOI - 10.1002/ajim.1058
Subject(s) - medicine , hexamethylene diisocyanate , asthma , subclinical infection , immunology , occupational asthma , bronchial hyperresponsiveness , methacholine , allergy , spirometry , occupational medicine , physiology , occupational exposure , environmental health , respiratory disease , lung , materials science , composite material , polyurethane
Abstract Background Diisocyanates are potent sensitizing agents and currently the most commonly identified cause of occupational asthma in industrialized countries. However, diisocyanate asthma is difficult to diagnose and exposure and host risk factors are unclear. Auto body shops, one of the most common hexamethylene diisocyanate (HDI) exposure settings, are particularly difficult to study due to their small size and episodic exposures. Surveillance studies of such workers are limited. Objectives We have initiated a cross‐sectional field epidemiologic study, Survey of Painters and Repairers of Auto bodies by Yale (SPRAY), to characterize the effects of diisocyanate exposures on actively employed auto body shop workers. Methods and Results We present here questionnaire, physiologic, immunologic, and exposure data on 75 subjects enrolled in the study. No overt cases of clinically apparent diisocyanate asthma were identified based on spirometry, methacholine challenge, peak flows, and symptoms. HDI‐specific lymphocyte proliferation was present in 30% of HDI‐exposed workers and HDI‐specific IgG in 34% of HDI‐exposed workers, but they were not associated. HDI‐specific IgE was detected in two workers. HDI‐specific lymphocyte proliferation, increased methacholine responsiveness, and symptoms of chest tightness and shortness of breath were more common in the most heavily HDI‐exposed workers, the painters. More long‐term follow‐up of this cohort should clarify the significance of these HDI‐specific immunologic responses, physiologic changes, and symptoms. Conclusions These findings demonstrate the presence of HDI‐specific immune responses in a large proportion of healthy HDI‐exposed workers. Am. J. Ind. Med. 39:587–597, 2001. © 2001 Wiley‐Liss, Inc.